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+This household comprises just one protein, SET7/9, which mono-methylates histone at H3K4 ninety two KMT7 was found to methylate, apart from histone, quite a lot of non-histone proteins, together with p53, DNA methyltransferase 1 (DNMT1), estrogen receptor alpha (ERα), nuclear factor kappaB (NFκB), and elements of the TATA binding protein (TBP) advanced, TBP-associated components TAF10 and TAF7 93 The consensus recognition sequence in [substrates](http://matzon.eyespeed.co.kr/bbs/board.php?bo_table=free&wr_id=881302) for SET7-mediated lysine methylation, Okay/R-S/T-K (target lysine is daring), can be recognized by the H3K4 demethylase KDM1A/LSD1, which is able to eradicating the methyl mark on most of those substrates 17 , 94 Therefore KMT7/KDM1A has emerged as a basic mannequin for dynamic lysine methylation of both histone and non-histone proteins.
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